CC: 1 week of redness of the eye
ID: 54 yo male with HIV/AIDS (CD4 count 96 2 months ago), noncompliant with medications, who presents with redness of the eye for 1 week and blurry vision for 1 month. Retinal exam was notable for inferior large chorioretinal scar with focal white lesion within the scar, consistent with CMV retinitis. AC tap was positive for CMV and negative for VZV or HSV. He was found to have a repeat CD4 count of 34.
American Academy of Ophthalmology webpage on ophthalmic abbreviations.
Pearls from morning report:
- For patients with CD4 < 50, remember to get regular ophthalmology exams every 3-6 months.
- CMV retinitis can be diagnosed based on fundoscopic exam alone – a vitreous tap is not required for diagnosis.
- CMV retinitis can present as part of the immune reconstitution inflammatory syndrome (IRIS).
When first discovered, ganciclovir was so efficacious that a placebo-controlled clinical trial could not be ethically be done – the FDA rejected the first application to market the drug. The pharmaceutical company who developed this drug, Syntex, gave the drug away for free for 5 years under compassionate use guidelines.
Want to read more?
MKSAP 17: Medical Knowledge Self-assessment Program. Philadelphia : American College Of Physicians, 2016. Print.
Jacobs DS, Trobe J, Libman H. Evaluation of the red eye. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on February 17, 2017)